Organic cation/carnitine transporter

Author: fyna

August undefined, 2024

WitrynaOrganic cation/carnitine transporters transport carnitine, drugs, and xenobiotics (e.g. choline, acetylcarnitine, betaine, valproic acid), and are expressed in muscle, heart, … Witryna26 mar 2013 · Major functional clusters for Up-Ex RAGs were glycosaminoglycan binding, cell migration, inorganic cation hemostasis, regulation of phosphorylation, regulation of apoptosis. Down-Nd RAGs were found in the clusters annotated as calcium binding region, domain EF hand, and mitosis.

Novel localization of OCTN1, an organic cation/carnitine transporter ...

WitrynaThe latter two transporters were previously reported to be decreased in T2D patients. 46 We speculate that the accumulation of choline in plasma of T2D patients can be due to the decreased levels (knockdown) of OCT1 and OCT2. As indicated in the same pathway, carnitine requires the action of OAT2 gene for interring hepatocytes . Witryna15 lut 2024 · The Carnitine-Acylcarnitine Carrier is a member of the mitochondrial Solute Carrier Family 25 (SLC25), known as SLC25A20, involved in the electroneutral exchange of acylcarnitine and carnitine across the inner mitochondrial membrane. It acts as a master regulator of fatty acids β-oxidation and is known to be involved in … imani fisher arrest

Organic Cation Transporters in Human Physiology, Pharmacology…

WitrynaThis chapter focuses on transporters for two major categories of solutes: organic cations and zwitterions. For organic cations, the … WitrynaPTHR24064:SF530 ORGANIC CATION/CARNITINE TRANSPORTER 4 1 hit; PTHR24064 SOLUTE CARRIER FAMILY 22 MEMBER 1 hit; PROSITE. View protein … Witryna3 lip 2024 · We assessed the impact of adding or removing free cholesterol on the function and localization of two hepatocellular uptake transporters: the Na + … list of hammer horror films

Organic cation/carnitine transporter

WitrynaIt is suggested that dietary clofibrate improved carnitine status and increased fatty acid oxidation in neonates, and Propionyl-CoA, generated from TC5 and TMPA, could stimulate the increased fatty acids oxidation rate induced by cl ofibrate as anaplerotic carbon sources. To investigate the role of peroxisome proliferator-activated receptor … WitrynaL-Carnitine and ALCAR are absorbed in the intestines (jejunum) mostly by the organic cation transporter 2 (OCTN2)[50][51] which is a sodium dependent transporter.[39] This transporters takes up L-carnitine molecules, and while ALCAR needs to be deacetylated (removal of the acetyl group) prior to absorption it can readily be …

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WitrynaSpecies specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2) Author links open overlay panel Kitti Szabó a b , Zoltán Nagy a 1 , Viktória Juhász a , Joseph K. Zolnerciks b , Attila Csorba b 2 , Zoltán Tímár b , Éva Molnár b , Petra Pádár b , William Johnson a , Erzsébet Beéry a ... Witryna3 lip 2024 · We assessed the impact of adding or removing free cholesterol on the function and localization of two hepatocellular uptake transporters: the Na + /taurocholate cotransporting polypeptide (NTCP) and the organic cation transporter 1 (OCT1). We used a cholesterol–MCD complex (cholesterol) to add cholesterol and …

WitrynaReferences: Amat di San Filippo C et al. Tyrosine residues affecting sodium stimulation of carnitine transport in the OCTN2 carnitine/organic cation transporter. J Biol Chem. 2004; 279(8):7247-53. Li F et al. Molecular spectrum of SLC22A5 (OCTN2) gene mutations detected in 143 subjects evaluated for systemic carnitine deficiency. Witryna1 dzień temu · Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter. Pflugers Arch. 2013; 465:1701–1714. doi: 10.1007/s00424-013-1307-z Crossref Medline Google Scholar; 81. Koepsell H. The SLC22 family with transporters of organic cations, anions and …

Witryna12 maj 2006 · Carnitine is a zwitterion essential for the beta-oxidation of fatty acids. We report novel localization of the organic cation/carnitine transporter, OCTN1, to mitochondria. We made GFP- and RFP-human OCTN1 cDNA constructs and showed expression of hOCTN1 in several transfected mammalian cell lines. WitrynaDive into the research topics of 'Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1'. Together they form a unique fingerprint. Ergothioneine Medicine & Life Sciences 100%

WitrynaSeveral SLC22 transporters in the human kidney and other tissues are thought to regulate endogenous small antioxidant molecules such as uric acid, ergothioneine, …

WitrynaOne of the compounds necessary in the process of mitochondrial β-oxidation and export of acyl moieties from peroxisomes is l-carnitine. Two Na-dependent plasma … list of hamlets in albertaWitrynaIntroduction: Organic cation transporters collectively called OCTs belong to three gene families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 OCTN2, SLC29A4 PMAT, SLC47A1 MATE1... list of hamburger toppingsWitryna6 kwi 2024 · The only known proton-coupled subclass of cation transporters is the organic cation/carnitine transporter (OCTN) 1. 82 In another study using an immortalized human brain endothelial cell line, uptake of memantine was not inhibited by ergothioneine, an OCTN1 substrate. 72 Indeed, the exact mechanism of memantine … imani family medical clinic jackson msWitryna1 cze 2001 · Organic cation/carnitine transporter 1: BLAST Add. Sequence: Expand table. Proteomic databases. PaxDb. Q9CAT6; ProteomicsDB. 250862; Expression. … imani flowers limitedWitryna20 cze 2003 · Spermatozoan maturation, motility, and fertility are, in part, dependent upon the progressive increase in epididymal and spermatozoal carnitine, critical for … list of hampshire county cricketersWitryna1 kwi 1999 · All of these transporters mediate the uptake of a variety of organic cations in a sodium-independent manner. Only OCTN2 has an additional property of sodium-dependent carnitine transport. Thus, OCTN2 mediates the uptake of organic cations in a sodium-independent manner and the uptake of carnitine in a sodium-dependent … list of hammer horror moviesWitryna25 kwi 2013 · This review article summarizes the main treatments for chronic obstructive pulmonary disease, their mechanisms, and the key evidence from trials supporting their use. Drug classes covered were short acting beta agonists (SABA), short acting muscarinic antagonists (SAMA), long acting beta agonists (LABA), long acting … imanifold kit