Cmaf transcription factor
WebApr 27, 2024 · The transcription factor c-Maf, belonging to the AP-1 family of basic region/leucine zipper factor, is highly expressed by mature Tfh cells, and is thought to … WebMay 15, 2015 · CMAF, an essential transcription factor for interleukin (IL) -10 production, is expressed in M2 macrophages committed to IL-10 production [22–24]. CD163 has been considered a M2-specific marker in macrophages [25–27]. Recently, we have demonstrated that the combined use of a macrophage marker, such as CD68 or CD163, together with …
Cmaf transcription factor
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WebNational Center for Biotechnology Information WebcMaf is a transcription factor with basic leucine zipper domains that mediate DNA binding to the cMaf recognition element (8,9). cMaf is expressed in monocyte and macrophage …
WebDec 10, 2024 · In this study, we identified the transcription factor c-Maf as a universal regulator of Tγδ17 cell differentiation and maintenance. Maf deficiency caused an absolute lineage block at the... WebInterestingly, loss of sAC did not impact the expression of Th17 lineage-defining transcription factors (such as Rorc and cMaf) but rather was required for CREB-dependent gene expression, which is known to support Th17 cell gene expression. Finally, topical application of small molecule sAC inhibitors (sACi) reduced imiquimod-induced ...
WebWhile regulators of Tγδ17 specialization restricted to various Vγ subsets are known, a commitment factor essential to all Tγδ17 cells has remained undefined. In this study, we … WebApr 1, 2024 · Here, we demonstrate that the transcription factor c-Maf is a critical controller for immunosuppressive macrophage polarization and function in …
WebSep 1, 2024 · Notably, c-Maf is usually expressed at the embryonic stage to promote cell differentiation but less expressed in healthy adult cells. c-Maf has long been proposed as …
WebOct 16, 2011 · Only two transcription factors, c-Maf and AhR, were induced tenfold over their expression in control conditions by the combination of IL-6 and TGF-β. lowest price on vitamix blenderWebThe transcription factor c-maf is exclusively expressed during the maturation of Th2 cells and in fully differentiated Th2 effectors. Indeed, the transgenic expression of c-maf in non … janice thompson obituaryWebDec 8, 2005 · The virus relies on host transcription factors, such as NFkB and NFAT for its transcription and expression. It has previously been shown that HIV-1 preferentially replicates in Th2 cells, but the mechanism of action for this finding remains unknown. c-maf is a Th2-restricted transcription factor that is critically important for differentiation ... janice thompson authorWebThe transcription factor c-Maf plays different roles in different types of cells. For instance, c-Maf is the IL-4–specific transcription factor in TH2 cells. Besides, c-Maf is a potent activator of the IL-10 gene expression whereas c-Maf could suppress the IL-12 p40 and p35 gene transcription in macrophages. We hypothesize that c-Maf could ... lowest price on viviscalWebcMaf is a transcription factor with basic leucine zipper domains that mediate DNA binding to the cMaf recognition element (8,9). cMaf is expressed in monocyte and macrophage lineages, as well as in T cell subsets (10,11). Studies of trans-genic cMaf T helper (Th) cells revealed that cMaf is important lowest price on wall e earth day funko popWebTranscriptome analysis of sorted PD-1 + CD8 + T cells revealed the transcription factor c-Maf as a potential major regulator of the gene module, including multiple coinhibitory molecules. Furthermore, c-Maf expressed in CD8 + T cells induced PD-1 expression and production of IL-10 as well as suppressed alloactivated CD4 + T-cell survival. janice thompson and state farmWebFeb 16, 2012 · We show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function in mice and humans. The development and function of several … janice thompson facebook