WebKey Points. Question What is the time to benefit of bisphosphonate therapy to prevent a nonvertebral fracture among postmenopausal women with osteoporosis?. Findings In this meta-analysis of 10 randomized clinical trials involving 23 384 postmenopausal women with osteoporosis, 12.4 months was needed to avoid 1 nonvertebral fracture per 100 women … WebAug 15, 2024 · Bisphosphonates are the most widely prescribed pharmacologic treatment for osteoporosis and reduce fracture risk in postmenopausal women by up to 50%. …
Bisphosphonates for Prevention of Bone Loss in ... - eClinicalMedicine
WebMay 1, 2000 · One class of agents used to treat osteoporosis is the bisphosphonates, which inhibit bone resorption, cause an increase in bone mineral density and reduce the risk of future fractures caused by... WebApr 13, 2024 · In a retrospective study, bisphosphonates did not appear to interfere with fracture healing. Bisphosphonates interfere with osteoclast activity and can affect bone remodeling. Thus, some clinicians have expressed concern that administering these drugs too soon after an osteoporosis-related fracture could interfere with fracture healing and … high intensity interval training workouts men
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WebFeb 18, 2024 · Bisphosphonates and Mid-Thigh Fractures. Atypical femur fractures have been reported in patients with osteoporosis. This fracture happens in middle of the thigh (between the hip and the knee) without any major injury. Most often patients report a deep, aching pain in the middle thigh several weeks to several months before the bone … WebIn the presence of a bisphosphonate-related atypical femoral fracture, the need for continued bisphosphonate therapy should be carefully reassessed. Also, imaging the contralateral femur is indicated because an incomplete asymptomatic or minimally symptomatic fracture is often present. WebJul 11, 2024 · The Rooney study establishes that we can prevent bone loss in young people treated with steroids, so the next key question is when this should be used. While the anti-fracture efficacy of bisphosphonates is not established in steroid-treated children, fracture prevention is the main reason for intervening. Steroid-induced bone loss is reversible high intensity kickboxing